Transplantationskohortenstudie STCS

Die Schweizerische Transplantationskohorte rekrutiert seit 2008 alle Patienten, die in der Schweiz ein neues Organ bekommen. Regelmässig werden die klinischen Daten erhoben, und Proben abgenommen. Diese vom Schweizerischen Nationalfonds und weiteren Quellen finanzierte Kohorte stellt weltweit ein einzigartiges Forschungsinstrument dar, um den mittel- und langfristigen Erfolg nach Transplantation zu erforschen. Im Rahmen dieser Kohorte werden aktuell >80 Projekte durchgeführt, die einzelne Fragestellungen im Detail analysieren, bei vielen auch unter Einbezug der Proben. Zürich stellt mit ca. 1/3 der Patienten das grösste Zentrum dar.

Publikationen

Wojtowicz A, Lecompte TD, Bibert S, et al. PTX3 polymorphisms and aspergillosis– a step towards personalized risk stratification in transplant recipients? Clin Infect Dis 2015: in press.

Wojtowicz A, Lecompte TD, Bibert S, et al. PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant. Clin Infect Dis 2015; 61(4): 619-22.

Wojtowicz A, Gresnigt MS, Lecompte T, et al. IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation. J Infect Dis 2015; 211(10): 1646-57.

Schmied L, Terszowski G, Gonzalez A, et al. Protection From Varicella Zoster in Solid Organ Transplant Recipients Carrying Killer Cell Immunoglobulin-Like Receptor B Haplotypes. Transplantation 2015.

Manuel O, Wojtowicz A, Bibert S, et al. Influence of IFNL3/4 polymorphisms on the incidence of cytomegalovirus infection after solid-organ transplantation. J Infect Dis 2015; 211(6): 906-14.

Berger C, Bochud PY, Boggian K, et al. The swiss transplant cohort study: lessons from the first 6 years. Curr Infect Dis Rep 2015; 17(6): 486.

Stern M, Hirsch H, Cusini A, et al. Cytomegalovirus serology and replication remain associated with solid organ graft rejection and graft loss in the era of prophylactic treatment. Transplantation 2014; 98(9): 1013-8.

Pison C, Magnan A, Botturi K, et al. Prediction of chronic lung allograft dysfunction: a systems medicine challenge. Eur Respir J 2014; 43(3): 689-93.

Gonzalez A, Schmitter K, Hirsch HH, et al. KIR-associated protection from CMV replication requires pre-existing immunity: a prospective study in solid organ transplant recipients. Genes Immun 2014; 15(7): 495-9.

De Geest S, Burkhalter H, Bogert L, et al. Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication nonadherence as risk factor for post-transplant nonadherence to immunosuppressives: the Swiss Transplant Cohort Study. Transpl Int 2014; 27(7): 657-66.

Burkhalter H, Wirz-Justice A, Cajochen C, et al. Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non-adherence: a cross-sectional, multi-center study. Clin Transplant 2014; 28(1): 58-66.

Bucheli E, Kralidis G, Boggian K, et al. Impact of enterococcal colonization and infection in solid organ transplantation recipients from the Swiss transplant cohort study. Transpl Infect Dis 2014; 16(1): 26-36.

Manuel O, Kralidis G, Mueller NJ, et al. Impact of antiviral preventive strategies on the incidence and outcomes of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant 2013; 13(9): 2402-10.

Koller MT, van Delden C, Muller NJ, et al. Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort. Eur J Epidemiol 2013; 28(4): 347-55.

De Geest S, Burkhalter H, Berben L, et al. The Swiss Transplant Cohort Study's framework for assessing lifelong psychosocial factors in solid-organ transplants. Prog Transplant 2013; 23(3): 235-46.

Burkhalter H, Wirz-Justice A, Cajochen C, et al. Validation of a single item to assess daytime sleepiness for the Swiss Transplant Cohort Study. Prog Transplant 2013; 23(3): 220-8.

Berger C, Boggian K, Cusini A, et al. Relevance of cohort studies for the study of transplant infectious diseases. Curr Opin Organ Transplant 2012; 17(6): 581-5.

 

Kontaktadresse

Klinik für Infektionskrankheiten und Spitalhygiene
Prof. Dr. Nicolas Müller
UniversitätsSpital Zürich
Rämistrasse 100
8091 Zürich